ParkinsonCanadaV1, Main, Exploration, bibRecord, 000529

Striatal blood–brain barrier permeability in Parkinson's disease

Identifieur interne : 000529 ( Main/Exploration ); précédent : 000528; suivant : 000530

Striatal blood–brain barrier permeability in Parkinson's disease

Auteurs : Madison T. Gray [Canada] ; John M. Woulfe [Canada]

Source :

Journal of Cerebral Blood Flow & Metabolism [ 0271-678X ] ; 2015.

RBID : PMC:4420870

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Biomarkers (metabolism), Blood Proteins (metabolism), Blood-Brain Barrier (metabolism), Blood-Brain Barrier (pathology), Capillary Permeability, Erythrocytes (metabolism), Erythrocytes (pathology), Female, Humans, Iron (metabolism), Male, Middle Aged, Parkinson Disease (metabolism), Parkinson Disease (pathology).
MESH :
- chemical , metabolism : Biomarkers, Blood Proteins, Iron.
- metabolism : Blood-Brain Barrier, Erythrocytes, Parkinson Disease.
- pathology : Blood-Brain Barrier, Erythrocytes, Parkinson Disease.
- Aged, Aged, 80 and over, Capillary Permeability, Female, Humans, Male, Middle Aged.

Abstract

In vivo studies have shown that blood–brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420870

DOI: 10.1038/jcbfm.2015.32
PubMed: 25757748
PubMed Central: 4420870

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><italic>In vivo</italic>
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La maladie de Parkinson au Canada (serveur d'exploration)

Striatal blood–brain barrier permeability in Parkinson's disease

Striatal blood–brain barrier permeability in Parkinson's disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.